Number of genotyped parent offspring trios (0-10000000):

Alpha level (0-1):

Maternal Genetic Effect - proportion of variance explained (0-1):

Paternal Genetic Effect - proportion of variance explained (0-1):

Offspring Genetic Effect - proportion of variance explained (0-1):

Maternal and Offspring Genetic Effect is in the opposite direction

Paternal and Offspring Genetic Effect is in the opposite direction

Power to detect maternal genetic effect (1 df test):

NCP of test to detect maternal genetic effect:

Power to detect paternal genetic effect (1 df test):

NCP of test to detect paternal genetic effect:

Power to detect offspring genetic effect (1 df test):

NCP of test to detect offspring genetic effect:

Alpha level is the type 1 error rate for the genetic association study.
Maternal genetic effect is the proportion of variance in the trait explained by maternal genetic effects at the locus.
Paternal genetic effect is the proportion of variance in the trait explained by paternal genetic effects at the locus.
Offspring genetic effect is the proportion of variance in the trait explained by offspring genetic effects at the locus.

If you have an effect size estimate and allele frequency for the genetic variant of interest, you can calculate the proportion of variance in the trait explained as (2*P*(1-P)*b^2)/VAR(trait), where P=allele frequency, b=effect size estimate.

If you use this utility in your research please cite: Tubbs J, Hwang LD, Luong J, Evans DM & Sham PC (in preparation). Modelling Parent-Specific Genetic Nurture in Families with Missing Parental Genotypes - Application to Birthweight and BMI.

If you encounter any errors please contact the developers at d.evans1@uq.edu.au